TRS (threonyl tRNA synthetase) controlled the synthesis of MUC1, and the TRS inhibitors, borrelidin (BN) and 5′-O-(N-(l-threonyl)-sulfamoyl)-adenosine (ThrAMS), also suppressed the migration of pancreatic cancer cells via MUC1. The gene discussed is MUC1; the disease is pancreatic neoplasm.