As suggested by some of the earlier studies, Charcot Marie Tooth disease (CMT), which is regarded as an incurable neurodegenerative disease, is related to the mutation of several different members of the ARSs family, including GRS (Antonellis et al., 2003), tyrosyl-tRNA synthetase (YRS) (Jordanova et al., 2006), alanyl-tRNA synthetase (AlaRS) (Weterman et al., 2018), methionyl-tRNA synthetase (MRS) (Gonzalez et al., 2013), tryptophanyl-tRNA synthetase (WRS) (Tsai et al., 2017), and histidyl-tRNA synthetase (HRS) (Vester et al., 2013). This evidence concerns the gene MARS1 and neurodegenerative disease.