GAS6 promoted the polarization of M1 macrophages into M2 macrophages, and the M2 macrophages were dependent on the secretion of FGF2 (fibroblast growth factor 2)/GRO-α (rowth-regulated oncogene-α)/M-CSF (macrophage colony-stimulating factor) to activate the surrounding cells, thereby promoting cancer metastasis (Nam et al., 2018). This evidence concerns the gene FGF2 and cancer.