On the same hand, the metastasis suppressor N-myc downstream regulated gene 1 (NDRG1) interrupted tumorigenic bidirectional crosstalk between pancreatic cancer cells and stromal pancreatic stellate cells, major contributors to local tumor growth and metastasis, partly through inhibition of IGF-1 and other potent mediators of cell migration, including hepatocyte growth factor (HGF) (33) (Figure 3). This evidence concerns the gene HGF and familial pancreatic carcinoma.