TUBB2B and Familial prostate cancer: In a recent in vitro study using human prostate cancer cell lines DU145 and PC3, periprostatic adipose tissue promoted prostate cancer resistance to the chemotherapy drug docetaxel through a mechanism involving paracrine IGF-1 upregulation of the β-tubulin isoform of tubulin Beta 2B Class IIb (TUBB2B) gene (31).