ERBB2 and gastric cancer: Moreover, a mechanistic study addressing the development of resistance to the anti- human epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab in HER2-positive (HER(+)) gastric cancer found that endoplasmic reticulum stress induces resistance to trastuzumab in HER2(+) gastric cancer cells by activating IGF-1R and FGFR1 signaling pathways, through a microRNA (miR)-301a-3p-dependent mechanism (76).