Due to their characteristics such as hyperandrogenemia, abnormal LH levels or insulin resistance, COS patients have the characteristics of a higher ovarian response, more oocytes retrieved, a larger number of transferable embryos, a lower fertilization rate, a higher incidence of ovarian hyperstimulation syndrome (OHSS) and pregnancy complications during the treatment process (3, 4). This evidence concerns the gene PLOD1 and ovarian hyperstimulation syndrome.