In this study, we found that PSG could significantly alleviate DSS-induced IBD by ameliorating the colon length loss, bodyweight loss, diarrhea, and bleeding feces and inhibiting the hepatic steatosis and cholestasis, reducing the high levels of ALT and AST in the serum of UC mice, which suggested that PSG can be regarded as a therapeutic candidate for IBD and IBD accompanied with SLI. Here, GPT is linked to inflammatory bowel disease.