In the pathological status of IBD, as the intestinal mucosa is damaged and intestinal permeability is increased, the intestinal bacteria along with their harmful products, such as lipopolysaccharides (LPS), TNF-α, and IL-6, will enter the liver through the portal vein, which would cause a liver inflammatory reaction and aggravate liver injury [13]. The gene discussed is TNF; the disease is inflammatory bowel disease.