Western blot assay showed that DSS increased the level of Keap1 and decreased the levels of Nrf2, HO1, and NQO1, while PSG significantly reversed the effects (Figures 7(c) and 7(d)), suggesting that PSG alleviated the oxidative stress of liver tissues in IBD mice by regulating the Keap1/Nrf2/ARE/HO-1 signaling pathway. The gene discussed is HMOX1; the disease is inflammatory bowel disease.