PROS1 and posterior cortical atrophy: Finally, from a clinical point of view, the presence of mutations in the VDBP gene in PCa patients, and decrease in the serum level of vitamin D as well as the increase in tPSA and fPSA levels, may increase the risk of PCa onset, therefore, determining the genotypes of these genes in different populations and linking them with the onset of PCa parallel to measuring serum PSA and vitamin D levels.