In conclusion, the frequencies of T/G genotypes of VDBP rs7041 SNP were significantly higher in PCa patients compared to control subjects [T/G vs. T/T, (61 (56.5%) vs. 61 (44.5%), p = 0.015] which was associated to increase the risk of disease by 2.2 folds [2.29 (1.17–4.49, p = 0.015)]. This evidence concerns the gene GC and posterior cortical atrophy.