Finally, we reported that in presence of both T/T and T/G + G/G genotypes, the free PSA/total PSA ratio was considerably higher in the control group when compared to PCa patients [TT: 0.64 vs. 0.19 ng/L, (p = 0.008) and T/G + G/G: 0.43 vs. 0.22 ng/L (p < 0.001)]. This evidence concerns the gene KLK3 and posterior cortical atrophy.