Alzheimer’s disease (AD) is the most prominent neurodegenerative illness of the Central Nervous System (CNS) progressed by abnormal cholinergic neurons loss, and deposition of extracellular amyloid-β and tau-proteins into plaques and neurofibrillary tangles (Scarpini et al., 2003; McKhann et al., 2011; Li et al., 2017). Here, MAPT is linked to Alzheimer disease.