There was a statistically significant link between FUNDC1 and the following biomarkers: CD8+ T cell (CD8A and CD8B), B cell (CD19 and CD38), M2 macrophage (CSF1R/CD115), M1 macrophage (IRF5), other T cell subsets (Tfh, Th1, Th2, Th9, Th17, Th22, and Treg), natural killer cell (XCL1), TAM (PDCD1LG2, CD80, and TLR7), dendritic cell (CD1C and ITGAX), and neutrophil (ITGAM and FUT4) in HCC. This evidence concerns the gene CD80 and hepatocellular carcinoma.