NOTCH1 and acute lymphoblastic leukemia: Zheng et al. also showed that according to the mutation frequency, the mutant genes in adult patients with ALL were in the following order: IL7R, NOTCH1, FLT3, TP53, FBXW7, PAX5, IKZF1, CREBBP, JAK3, JAK1, PHF6, and PTEN [23], from which we observed that most of their mentioned mutant genes were consistent with the mutant genes identified in this present study.