GPX4 and cardiac hypertrophy: Iron-catalyzed disorder of intracellular lipid peroxide metabolism leads to GPX4 inactivation, destruction of the redox balance, and ferroptosis; these findings show that GPX4 plays an important role in the pathophysiology of cardiovascular diseases such as atherosclerosis, cardiac hypertrophy, cardiomyopathy, and AAA (18, 53).