AGT and aortic aneurysm: While there is limited evidence for a mechanistic link between antimicrobial use and aortic disease in humans, LeMaire et al. (22) found that wild-type mice given a high-fat diet, angiotensin II infusion, and exposure to ciprofloxacin experienced more severe aortic wall degeneration and a higher incidence of aortic aneurysm, dissection, and rupture, compared with test control mice.