POMC and adrenal cortex carcinoma: The establishment of the ACTH-modulated membrane guanylate cyclase signaling pathway, originating in the pituitary gland of the brain and terminating at its target site in the isolated fasciculate cell of the adrenal cortex, at the morphological, physiological, and biochemical levels made it possible to compare it with its counterpart adrenocortical carcinoma 494 cells (Sharma, 1976, 1978, 1985; reviewed in Sharma and Criss, 1978).