WEE1 and cancer: It is then possible that (i) AUT-PK 500 is an adrenocortical cellular oncogene; (ii) the protein kinase is a cause for either immortalization or its subsequent steps in the adrenal cell; (iii) low-level expression of the enzyme is necessary for cellular growth with differentiation, but it is only when the gene expression is excessive that the cell acquires cancer phenotype (Reviewed in Sharma et al., 1988).