Formerly, it was reported that the anti-apoptosis effect of BBR in Parkinson's disease (PD) and Alzheimer's disease (AD) might take place through the restoration of Bcl-2/Bax and Bcl-xl/Bax (Ma et al., 2017), and our findings were in accordance with theirs. Here, BCL2L1 is linked to early-onset autosomal dominant Alzheimer disease.