Although specific types of estrogens were distinguished, the picture became more complex and difficult, because the recognition of classical estradiol receptors ( and ) has a different effect on the development of prostate cancer and the current paucity of models of prostate cancer and its covariates due to the conflicting nature of the results makes the involvement of estrogens (i.e., regardless of whether participants increase or decrease the prevalence of prostate cancer) a difficult question to answer [18]. The gene discussed is ESR1; the disease is prostate cancer.