In the treatment of hypertension, the principle of “early, timely, and combined use” is well established, and calcium channel blockers are usually used as first-line agents in combination with other antihypertensive drugs, such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and β- and α-blockers. The gene discussed is ACE; the disease is Hypertension.