IFNL3 and COVID-19: First, a score for the early predictor of COVID-19 hyper-inflammation status named the steroid predicting score (SP-score), composed of a body temperature ≥ 38.5°C, respiratory rate ≥ 22 breaths/min, SpO2 ≤ 95%, a duration from symptom onset to treatment initiation ≥ 7 d, AST ≥ 40 U/L, LDH ≥ 340 U/L, Ferritin ≥ 800 ng/mL, and IFN-λ3 ≥ 20 pg/mL, showed good AUC values in the ROC analysis.