A total of 21 NRGs were identified with significant differential expression between the non-tumor and ccRCC groups, including 4 downregulated (MYNC, GATA3, IDH2, and BACH2) and 17 upregulated (TRAF2, LEF1, FAS, TNFRSF1B, EGFR, MYC, TLR3, BNIP3, AXL, CD40, ALK, MLKL, PLK1, ZBP1, FASLG, TERT, and CDKN2A) genes (Figure 1A). The gene discussed is LEF1; the disease is nonpapillary renal cell carcinoma.