We screened out 21 differentially expressed genes from 67 NRGs and compared their expression in non-tumor and tumor tissues, including 4 downregulated (GATA3, MYCN, IDH2, and BACH2) and 17 upregulated NRGs (TRAF2, LEF1, FAS, TNFRSF1B, EGFR, MYC, TLR3, BNIP3, AXL, CD40, ALK, MLKL, PLK1, ZBP1, FASLG, TERT, and CDKN2A). This evidence concerns the gene IDH2 and neoplasm.