A total of 21 NRGs were identified with significant differential expression between the non-tumor and ccRCC groups, including 4 downregulated (MYNC, GATA3, IDH2, and BACH2) and 17 upregulated (TRAF2, LEF1, FAS, TNFRSF1B, EGFR, MYC, TLR3, BNIP3, AXL, CD40, ALK, MLKL, PLK1, ZBP1, FASLG, TERT, and CDKN2A) genes (Figure 1A). This evidence concerns the gene LEF1 and neoplasm.