Interestingly, the inability to form succinate from succinyl-CoA due to SUCLG2 repression characteristic of RA in the tricarboxylic acid (TCA-) Cycle with subsequent accumulation of Acetyl-CoA has been shown to skew naïve CD4+ T cells to the short-lived effector subtype (SLECs). Here, CD4 is linked to rheumatoid arthritis.