On the other hand, traditional chemotherapy could reverse the immunosuppressive tumor micro-environment, including the depletion of immunosuppressive cells, like CD4+CD25+FOXP3+ regulatory T (Treg) cells, myelogenous suppressor cells (MDSCs) and M2 like tumor associated macrophages (TAMs) (24, 25), and the activation of immune effector cells, including M1 like TAMs (26), DCs (27) and CTLs (28). Here, CD4 is linked to neoplasm.