FOXP3 and neoplasm: On the other hand, traditional chemotherapy could reverse the immunosuppressive tumor micro-environment, including the depletion of immunosuppressive cells, like CD4+CD25+FOXP3+ regulatory T (Treg) cells, myelogenous suppressor cells (MDSCs) and M2 like tumor associated macrophages (TAMs) (24, 25), and the activation of immune effector cells, including M1 like TAMs (26), DCs (27) and CTLs (28).