IRAK4 and cytomegalovirus infection: In the setting of organ transplant, donor and/or recipients genes encoding pattern recognition molecules and receptors such as TLR (TLR2, 4 and 9) or MLB (MBL2), interferon (IFNL3/IL28B), cytokines (IL12, IL10), cytoplasmic sensors (AIM2, IFI16, IRAK2, IRAK4) and immune regulatory membrane-associated proteins (human programmed death-1, PD1) have been linked with an increased risk of CMV infection and disease among different transplant populations either solid organ or allogenic stem cell transplant patients (14–25).