To that end, we investigated SNPs from innate immune genes critically involved in eliciting effective anti-viral immune responses (IFNL3/IL28B, MBL2, TLR2, TLR3, TLR4, TLR7, TLR9, MYD88, IRAK2, IRAK4, AIM2, IFI16) to further explore their individual or combined potential impact in the risk of CMV infection. The gene discussed is IFI16; the disease is cytomegalovirus infection.