In human studies, 57 SLE patients demonstrated an association between serum anti-NR2A/B antibodies and a reduction in short-term memory and depressed mood (134), while another cross-sectional study of 133 SLE patients revealed that serum anti-NR2A/B antibodies displayed impairments in sustained attention, planning abilities and executive function (135). The gene discussed is GRIN2A; the disease is systemic lupus erythematosus.