Antibodies against NMDA receptor NR2A/B subunits (anti-NR2A/B antibodies) are found in the sera of 30-40% of SLE patients and is a convincing candidate as a pathogenic factor in mediating cognitive dysfunction in SLE patients, fulfilling 4 out of 6 stringent pathogenicity criteria for autoantibodies (125, 129). Here, GRIN2A is linked to systemic lupus erythematosus.