IgG+ CLL is phenotypically similar to IgM/IgD CLL (12), with a highly skewed immunoglobulin heavy variable (IGHV) gene repertoire that is distinct from IgM+ CLL and overuses the IGHV4-34 and IGHV4-39 genes (11). This evidence concerns the gene CD40LG and B-cell chronic lymphocytic leukemia.