Furthermore, platelet depletion resulted in vascular remodeling demonstrated by increased pulmonary arterial medial wall thickness (2.5-fold, p < 0.001), determined on α-SMA-stained sections (Figures 2C,H) and caused right ventricular hypertrophy (RVH), demonstrated by a significantly increase in the ratio RV/LV free wall thickness (1.5-fold, p < 0.01, Figures 2D,I). This evidence concerns the gene ACTA1 and Right ventricular hypertrophy.