Taken that tibia from 19-month-old aged female mice showed downregulated cyclins, CCNA2, CCND3, CCNE1-2, the upregulation of miRNA-15b-5p, miR-24-3p, and miR-92b-3p (and consequent silencing of cyclins) can be related, at least in part, to declines in bone mass and fracture in older adults, in the context of obesity. The gene discussed is CCNA2; the disease is obesity disorder.