This negative control by aging-deregulated miRNAs into circulating adipocytes-derived EVPs on some tumor cells seems to be related to inhibiting cellular proliferation, in agreement with the cellular senescence concept that is considered as a mechanism for tumor suppression that would inhibit the proliferation of abnormal cells, acting on regulatory molecules of cell cycle, such as cyclins, E2Fs, and several kinases, CDKs and MAP kinases, above discussed. The gene discussed is CCNL2; the disease is neoplasm.