Considering the controversial aspects between canonical pathway z-score (predicted positive regulation) and direct effect on PTEN by miR-92b-3p (predicted negative regulation), it is possible to infer the role of miRNAs on molecules that comprise its exceptionally complex regulation pathways, as different transcription factors pathways, such as c-JUN and nuclear factor-kappa B, and miRNAs at the post-transcriptional level, such as mir-221, what can have consequently a tumor promoter role (He et al., 2021). The gene discussed is PTEN; the disease is neoplasm.