ADAMTS1 and Alzheimer disease: Since ADAMTS1 is implicated to hold associations with AD (Kunkle et al., 2019) and its product ADAMTS1 exhibits proteolytic activity (Shindo et al., 2000), we investigated whether ADAMTS1 participated in APP metabolism through co-transfecting HEK 293T cells with swAPP and ADAMTS1. Western blot data showed that the introduction of ADAMTS1 resulted in a novel APP hydrolysate [about 75–85 kDa, soluble APP fragment cleaved by ADAMTS1 (sAPPATS1)] accompanying traditionally recognized ones (Figure 4A).