ADAMTS1 and Alzheimer disease: Similar pattern seemed to be present here, that was, though the rare variant c.–2067A > C at ADAMTS1 promoter had an MAF of 0.26%, it triggered enhanced fundamental transcription of ADAMTS1. However, given the limitation of sample size in identifying rare variants, the correlation of c.–2067A > C with AD still requires larger-scale cohort for further analysis.