Huang et al. (2020) showed that HG induced the expression of βarr-2, but not βarr-1, and HG reduced the interaction between βarr-2 and I-κBα. However, this effect was reversed by butyrate via GPR43, suggesting that GPR43-β-arrestin-2 signalling could be a prospective target for DKD treatment. Here, ARRB2 is linked to diabetic kidney disease.