Enalapril is able to modulate the inflammatory response through increasing IL-10 and increasing splenic CD4+ T lymphocyte activation and migration, which disagrees with the observations of De Albuquerque et al. in 2004 where IL-10 and TGF-β were decreased after captopril treatment of lupus-prone mice [62, 72]. The gene discussed is IL10; the disease is systemic lupus erythematosus.