Hemoglobin released by the disintegration of red blood cells in the blood can be decomposed in the presence of HO-1 to produce Fe2+, CO, and biliverdin, resulting in iron overload in the brain, where the nonheme iron content can increase by threefold; the main mechanisms of neurodegeneration in hemorrhagic stroke are iron and heme-induced ROS production, amplification of inflammatory responses, direct toxic effects of iron and heme, and glutamate-induced excitotoxicity [24, 25]. The gene discussed is HMOX1; the disease is hemorrhagic stroke.