The results showed that the IINS-AFP classification (AUC: 0.767; 95% CI: 0.675-0.858; Table 4) was more predictive of OS in HCC patients than IINS (AUC: 0.760; 95% CI: 0.668-0.851; Table 4), although the difference was not statistically significant (P = 0.875). This evidence concerns the gene AFP and hepatocellular carcinoma.