In addition, the time-dependent ROC curves showed that both IINS (12-month AUC: 0.650, 24-month AUC: 0.670, 36-month AUC: 0.880) and IINS-AFP classification (12-month AUC: 0.720, 24-month AUC: 0.760, 36-month AUC: 0.970) performed well in predicting OS for HCC patients (Figure 5). The gene discussed is AFP; the disease is hepatocellular carcinoma.