GH/GHR could mediate the TME and signal transduction including JAK/STAT, MAPK/phosphatidyl inositol 3 kinase (PI3K)/Akt, matrix metallopeptidase 2, and VEGF/VEHGR in gastric cancer, breast cancer, and melanoma (16, 20–22). This evidence concerns the gene MMP2 and breast carcinoma.