PKM and neoplasm: The Warburg effect-related limiting enzymes including hexokinase-2 (HK2), phosphofructokinase-2 (PFK2), pyruvate kinase-2 (PKM2), pyruvate dehydrogenase kinase-1 (PDK1), and lactate dehydrogenase (LDH), modulate glycolysis rate, lactate production, and ATP level in tumor cells and influence tumor cell biosynthesis, the immune response, and progression [32–34].