PMCH and Anxiety: Kim et al. (2015) found that transcriptionally upregulated MCH expression induced by repeated stress promoted anxiety-like behaviors, and that the key nucleus involved in the response seems to be the BLA (Kim and Han, 2016c). As known, the BLA is the “fear and stress center” of the limbic system and expresses MCHR1 (Jang J. H. et al., 2018), which suggests a possible functional link between the LHA and the BLA areas in anxiety and related symptoms.