Animals with paclitaxel-induced neuropathy and mechanical hypersensitivity had decreased expression of Nrf2 protein in the dorsal root ganglions (Zhao et al., 2019; Kumar Kalvala et al., 2022), which was reversed by treatment with drugs that have antihyperalgesic activity such as the cannabinoids cannabidiol and tetrahydrocannabivarin (Kumar Kalvala et al., 2022). Here, NFE2L2 is linked to neuropathy.