In hyperglycemia, the endothelial markers CD31 and VE-cadherin are decreased in ECs, and VE-cadherin disruption leads to the loss of cell-to-cell contact in EC monolayers and mediates Sema4D/PlexinB1 to induce EC dysfunction (Portillo et al., 2017; Thomas A. A. et al., 2019; Wu et al., 2020). The gene discussed is CDH5; the disease is Hyperglycemia.