MARK2 and hypertensive disorder: FFA contribute to the development of hypertension by causing a sustained accumulation of DG and TG in the liver and muscle, leading to endothelial diastolic dysfunction, inactivating NO oxidation and activating some serine/threonine kinases (Kulkarni et al., 2013), which may induce hypertension lipotoxicity (Kulkarni et al., 2013; Hu et al., 2010).