That study found that the expression of GSDMD and its pyrogenic-induced fragment GSDMD-N were upregulated in NAFLD/NASH liver tissues, and the increased level of GSDMD-N protein in the liver was correlated with NAFLD activity score and fibrosis (Xu B. et al., 2018). The gene discussed is GSDMD; the disease is metabolic dysfunction-associated steatotic liver disease.