NLRP3 and metabolic dysfunction-associated steatohepatitis: The cell membrane pore permeability and the number of pyroptotic cells significantly decreased after treatment with Antcin A. It worked by binding to NLRP3 and inhibiting the assembly and activation of the NLRP3 inflammasome, further mediating the inflammatory response and pyroptosis and thereby improving NASH (Ruan et al., 2021).