KEGG pathway analysis indicated that CASR exerted regulatory effects through several pathways, including neuroactive ligand-receptor interaction, calcium signaling pathway, estrogen signaling pathway, serotonergic synapse, cholinergic synapse, PI3K-Akt signaling pathway, sphingolipid signaling pathway, platelet activation, bile secretion, retrograde endocannabinoid signaling, and non-alcoholic fatty liver disease (Figure 2B). Here, CASR is linked to metabolic dysfunction-associated steatotic liver disease.