The PI3K/AKT pathway is an important intracellular signal transduction pathway that mediates a variety of biological effects, including regulation of vascular endothelial formation, inflammatory response, cardiomyocyte apoptosis, and autophagy, as well as the downstream mTOR signaling pathway to regulate lipid metabolism, which has a substantial impact on the development of cardiovascular diseases. Here, AKT1 is linked to cardiovascular disorder.