In addition, p53 signaling is related to immune and apoptosis-related functions of SARS-CoV-2 infected cells (Rahaman et al., 2021) because SARS-CoV-2 could favor tumor growth by inducing MDM2-mediated p53 downregulation (Tanda et al., 2022) and target mTOR and RPS6KB1 to inhibit viral replication in the human respiratory tract and lung cells (Ramaiah, 2020). Here, MDM2 is linked to neoplasm.