TP53 and neoplasm: In addition, p53 signaling is related to immune and apoptosis-related functions of SARS-CoV-2 infected cells (Rahaman et al., 2021) because SARS-CoV-2 could favor tumor growth by inducing MDM2-mediated p53 downregulation (Tanda et al., 2022) and target mTOR and RPS6KB1 to inhibit viral replication in the human respiratory tract and lung cells (Ramaiah, 2020).