Considering that the SARS-CoV-2 viral life cycle starts with the binding of the S-RBD to the host ACE2 receptor, the S protein, especially the S-RBD, is considered a key molecular target for the development of vaccines, therapeutic agents, and diagnostic methods against COVID-19 (Pandey et al., 2021; Souza et al., 2021; Tan et al., 2021; Zahradník et al., 2021; Gyebi et al., 2022). The gene discussed is PROS1; the disease is COVID-19.