Previous studies have shown that the increase in the number of macrophages can significantly promote angiogenesis after stroke (Manoonkitiwongsa et al., 2001), and T helper 17 cells promote angiogenesis and increase cerebral blood flow in the ischemic penumbra by partially promoting EC migration and sprouting; cellular infiltration of Th2 increases IL-4, IL-10, and TGF-β, and decreases IFN-γ expression, which are key factors in promoting angiogenesis during stroke recovery (Kwee et al., 2018; Zhu et al., 2021). This evidence concerns the gene IL4 and Stroke.