As previously described, internal circadian dysregulation may contribute to the incidence of stroke; conversely, the stroke itself can lead to the desynchronization of endogenous circadian rhythms by directly affecting the SCN, or by disrupting the clock mechanisms of neurons, glia, and endothelial cells (Kostenko and Petrova, 2018; Fodor et al., 2021). The gene discussed is CLOCK; the disease is Stroke.