PLAT and ischemic stroke: Although the current intravenous (IV) recombinant tissue plasminogen activator (rt-PA) and endovascular mechanical thrombectomy have a major impact on the outcome of recanalization of intracranial vascular occlusions, the narrow therapeutic window and risk of hemorrhage result in less than 22% of patients with ischemic stroke using rt-PA, and the majority of patients still have some degree of disability, highlighting the need for new targets and therapies to improve neuro recovery and rehabilitation after ischemic stroke (Fraser et al., 2017; Barthels and Das, 2020; Marko et al., 2020).