Circadian disruption induced by a genetic mutation also caused severe cardiovascular dysfunction (Chellappa et al., 2019), and mutations of core clock genes (i.e., Bmal1, Clock, and Npas2) could decrease mean blood pressure and disrupt sympathoadrenal responses (norepinephrine and epinephrine) to stress, which contribute to the incidence of stroke (Curtis et al., 2007). Here, CLOCK is linked to stroke disorder.