Liver enzyme indicators in serum were significantly higher in the HCV mono-infected patients than in the healthy controls, and co-infection with HIV may further exacerbate abnormal liver function, as reflected by a further increase in the glutamate transaminase, glutamic oxaloacetic transaminase, and gamma-glutamyl transpeptidase levels in HIV/HCV co-infected patients compared to in HCV mono-infected patients. Here, GGTLC1 is linked to coinfection.