JAK1 and viral infectious disease: NS1 and NS4B interact with TBK1 and block its oligomerization. NS2B3 degrades JAK1 and reduces virus-induced apoptotic cell death. This inhibits IFN response. Cooperation of NS1, NS4B, and NS2B3 enhances viral infection by blocking IFN-induced autophagy degradation of NS2B3 in HEK293T cells.