Severe forms of DENV infection are characterized by the excessive release of proinflammatory cytokines and chemokines, such as TNF-α, IFN-γ, IL-6, IL-1β, MIF (macrophage migration inhibitory factor), IL-8, CXCL10, and CCL2 [9,10,11,12] which leads to the development of a cytokine storm accompanied by dengue hemorrhagic fever and dengue shock syndrome [13,14], and is hypothesized to be a mechanism for vascular leak [15,16,17,18,19]. The gene discussed is MIF; the disease is Dengue hemorrhagic fever.