The presence of HMGB1 in the serum has been reported in patients with different diseases such as sepsis, cancer, and viral infections (e.g., HBV, HBE, HIV, WNV) as well as hemorrhagic-type viruses, including DOBV, where it has been proposed as a possible biomarker of disease progression in severe cases. This evidence concerns the gene HMGB1 and viral infectious disease.