The presence of HMGB1 in the serum has been reported in patients with different diseases such as sepsis, cancer, and viral infections (e.g., HBV, HBE, HIV, WNV) as well as hemorrhagic-type viruses, including DOBV, where it has been proposed as a possible biomarker of disease progression in severe cases. The gene discussed is HMGB1; the disease is Sepsis.