Another study reported by Rus et al. (2016) quantified HMGB1 levels in sera from patients infected with hemorrhagic viruses such as Hantavirus, Dobrava-Belgrade virus (DOBV), Puumala virus (PUUV), Crimean-Congo hemorrhagic fever (CCHF), and hemorrhagic fever with renal syndrome (HFRS). The gene discussed is HMGB1; the disease is hemorrhagic fever with renal syndrome.