For six of these pathways IPA predicted decreased activity: CDC42 signaling, Sumoylation Pathway, Cell Cycle: G2/M DNA Damage Checkpoint Regulation, Neuroprotective Role of THOP1 in Alzheimer’s Disease, PD-1,PD-L1 cancer immunotherapy pathway and ILK Signaling. Here, THOP1 is linked to early-onset autosomal dominant Alzheimer disease.