Although there is recent evidence that SIRT1 represses the AIM2 (absent in melanoma inflammasome) innate immune response to infection by DNA viruses, promoting survival and proliferation of HPV positive cells, there is no evidence of the downregulation of AIM2 associated proteins such as interleukin-1β or caspase among our list of significantly differentiated proteins [54]. This evidence concerns the gene AIM2 and melanoma.