As shown in Figure 4B,C, the wtRGNNV infection increased mRNA level of CRP in zebrafish larvae as compared with that in non-infection control, whereas rRGNNV-B2-M1 and rRGNNV-B2-M2 infection caused a significant decrease in the mRNA expression of CRP as compared to wtRGNNV. This evidence concerns the gene CRP and infection.