Prior work has shown that distinct subsets of activated ISGs are impactful for determining the outcome of a particular virus infection: IFITM1 and IFITM3 restrict ZIKV at an early step in replication [19]; IFITM3, Tetherin, and TRIM69 have been shown to inhibit VSV infection and replication [40,41]; and PKR and IFIT1 can restrict translation of PIV5 mRNAs [42,43]. This evidence concerns the gene IFITM3 and viral infectious disease.