These pathways included EIF2 signaling; mitochondrial dysfunction; oxidative phosphorylation; regulation of eIF4 and p70S6K signaling; phagosome maturation; mTOR signaling; remodeling of epithelial adherens junctions; caveolar-mediated endocytosis signaling; Huntington’s disease signaling; and phospholipase C signaling. This evidence concerns the gene RPS6KB1 and juvenile Huntington disease.