TJP1 and infection: Over the last two decades it has become increasingly apparent that these pathological features, often seen in severe SARS-CoV-1 and -2 infections, can largely be attributed to two properties of the hCoV envelope (E) protein: its ion-channel (IC) activity and its ability to interact with host cell proteins through its postsynaptic density protein 95 (PSD95)/Drosophila disc large tumor suppressor (Dlg1)/zonula occludens-1 protein (ZO-1) (PDZ)-binding motif (PBM) [15,17,18,24,25,26,27].