We suggest that a number of factors, including obesity, comorbidities, current or former smoking, the percentage of lung involvement on CT, lower SpO2, leukocytosis, neutrophilia, lymphopenia, higher IG count, NLR, and higher CRP, PCT, IL-6, D-Dimer, LDH, hs-TnI, CK-MB, myoglobin, NT-proBNP, creatinine, urea and GGT levels, lower EGFR, albumin, calcium and vitamin D3 levels, and possibly a decrease in RBC counts and hemoglobin and hematocrit levels and an increase in CK levels in the course of hospitalization may be associated with poor outcomes of COVID-19. This evidence concerns the gene EGFR and obesity due to melanocortin 4 receptor deficiency.