HBE1 and liver disorder: Accordingly, the relative dynamics of wild-type and HBeAg-defective HBV populations in children before and after HBeAg to anti-HBe seroconversion favor the hypothesis that the latter are selected after triggering of inflammatory liver disease [71,72], possibly because of their ability to escape the immune response once its activation has occurred and HBeAg immune tolerance is lost [73,74,75].