The most frequently proposed pathophysiological mechanism for the link between periodontitis and COVID-19 is based on a series of inflammatory cascades characteristic of both pathologies; thus, the inflammatory components of periodontal disease (TNF-α, IL-1 α, IL-1 β, and IL-6) could be systemically disseminated through the bloodstream, adding an additional burden to the cytokine storm encountered in severe forms of COVID-19 [40,41,42,43]. This evidence concerns the gene TNF and COVID-19.